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Original Research
1.
Disposition kinetics of long acting moxifloxacin
following intravenous administration in sheep -
Chirag M. Modi, Shailesh K. Mody, Hitesh B. Patel
Vet World. 2012; 5(9): 517-521
doi:
10.5455/vetworld.2012.517-521
Abstract
Aim:
The objective of the present study was to study the
disposition kinetics and dosage regimens of long
acting moxifloxacin following intravenous
administration at the dose rate of 7.5 mg/kg-1 b.
wt. in six male sheep and to calculate dosage
regimens of the same in sheep.
Materials and
Methods: The study was conducted using six
healthy male sheep. Long acting Moxifloxacin
solution (10 % moxifloxacin in solution with L-
arginine, N-butyl alcohol and benzyl alcohol) was
injected in jugular vein and periodical blood
samples were collected from contra-lateral jugular
vein in test tubes containing 30-50 IU heparin
(anticoagulant) at 0.083 (5 min), 0.166 (10 min),
0.5, 1, 2, 4, 8, 12, 24, 36, 48, 60, 72 and up to 96
h post administration of drug. Drug concentration in
plasma was determined using High Performance Liquid
Chromatography (HPLC) with Fluorescence Detector.
The blood concentrations versus time data were
analyzed using software.
Results: After
single dose intravenous administration of long
acting moxifloxacin the plasma concentration of
0.016 ± 0.001 µg/ml-1 was maintained for up to 72 h.
Distribution half-life (t1/2) and elimination
half-life (t1/2) were 1.637 ± 0.053 h, and 12.130 ±
0.202 h, following IV administration. The mean
values of apparent volume of distribution Vd(area)
5.436 ± 0.135 L/kg-1 as well as mean residence time
10.02 ± 4.787 minute were detected with IV
administration.
Conclusion: The long acting
Moxifloxacin @ the dose 7.5 mg/kg IV maintains the
effective therapeutic concentration in the plasma of
sheep for up to 72 hours. The long acting
Moxifloxacin at this dose rate can be used to treat
sensitive bacteria causing infectious diseases in
sheep.
Keywords: Disposition kinetics,
Intravenous, Long acting Moxifloxacin, Sheep.
